CBD Dosage and How Bio-Availability Changes Everything


Consumers have various questions regarding CBD, and many of those pertain directly to how much CBD they should be using. To thoroughly understand how much CBD you should be utilizing, you must understand some of the standard terms and aspects surrounding the administration of this phytocannabinoid. These include dosage aspects and a term known as bioavailability.

The Bioavailability of CBD

Seeing how bioavailability has a direct impact on how much of a substance you should take, let's first look at this term and what it means more in-depth. Bioavailability is defined as being the amount of and rate at which your bloodstream absorbs something. Each method of consuming CBD offers a different bioavailability rate.

This means that how you consume CBD has a direct effect on the bioavailability and how much CBD is actually being absorbed by your body. Not only does the method of consumption play a vital role in bioavailability, so does the form of CBD you are consuming, but more on that later.

Average CBD oil that you will find on the market today that is administered sublingually has between a 13 and 19% bioavailability rate. CBD in which you ingest orally such as in food, beverages, or a capsule form, have a lower bioavailability rate falling between 6 and 19% on average. These numbers, however, can be drastically higher when the CBD oil being utilized has been through a process known as nano emulsification, which we will cover below!

So now that we know what bioavailability is and the rate of some of the most common consumption methods, let's take a look at why bioavailability matters when it comes to determining the perfect dose of CBD for you. But first, it is important to know why the bioavailability of CBD is as low as it is.

So Why is the Bioavailability of CBD So Low?

CBD is naturally a fat-soluble compound. Fat-soluble compounds are not readily absorbed by the body, which consists mostly of water. So initially, little CBD is absorbed, and then a process known as Pharmacokinetics comes into play. Pharmacokinetics is the process in which compounds are broken down by the body.

Unfortunately, digestive acids and enzymes destroy the majority of CBD before it is ever absorbed into the bloodstream. CBD that does make it past the intestinal wall is then metabolized via the liver before making its way to the rest of the body.

What Other Factors Effect Bioavailability?

Aside from natural processes of the body and the chemical composition of CBD, there are other aspects that also play a vital role in the bioavailability of CBD for each individual.

  • Health Conditions: Individuals that suffer from impaired liver function may experience a higher bioavailability rate as the liver is vital in the process of removing CBD from circulation and has a direct impact on the absorption of CBD as well as how long it stays in the body before being excreted. In one study, those who suffer from severe liver impairment had higher CBD blood concentrations for longer periods than those without liver impairment. Other health aspects, such as neurological conditions may also affect bioavailability but not in a positive way. For example, studies in the past have shown that Huntington's disease patients have very low peak absorption levels and receive minimal benefit from CBD products.
  • To Eat or Not to Eat:When it comes to consuming CBD products, according to research, the absorption rate of CBD into the bloodstream is much higher when CBD is consumed on a full stomach in comparison to an empty one. Eating a diet that is higher in fat before consuming CBD may also help the fat-soluble compound to be better broken down and absorbed by the body.
  • Other Ingredients in CBD Products:Within some CBD products, you can find ingredients such as piperine. Piperine is a compound common in black pepper, that according to research, stimulates the transporting molecules in the body that are responsible for CBD crossing the intestinal membrane into the bloodstream. According to one study, CBD oral supplements formulated with piperine provide a 6-fold increase in the absorption of CBD into the bloodstream.

How Bioavailability Affects CBD Dosage

Bioavailability plays a direct factor in the dosage of CBD needed by consumers as it directly affects how much CBD is actually being utilized by your body. Let me explain with an example. Let's say you have a 1500 mg CBD tincture, and each one ml dropper offers a serving size a 50 mg of CBD. 

What consumers would like to believe is that they are receiving 50 mg of CBD with each dose. However, with the bioavailability rate of this delivery method being between 13 and 19% in all actuality when do you consume 50mg of CBD, only 6.5-9.5 mg of CBD is entering your bloodstream. 

Seeing how each person is affected differently by phytocannabinoids such as CBD, many consumers find that they have to titrate often until they find what works best for them. As CBD works differently for each person, it also works differently for each condition that it may potentially treat. This means that what may work for one person successfully for anxiety may not work the same for somebody looking to address inflammation.

Knowing the bioavailability rate of the consumption method that you are choosing will help you to better determine what dose of CBD will work best for you.

NanoCBD and the Bioavailability of Ultradiol’s CBD Ultragels

Now that you have learned more about bioavailability and how it directly affects the dosage of CBD one should be consuming, let’s take a closer look at how nano-CBD products such as those offered here at Ultradiol are a much better choice for your CBD needs.

Nano-CBD has undergone a process known as nano emulsification. This process breaks down the CBD molecules into water-soluble nanoparticles, unlike regular CBD, which is fat-soluble and not readily processed or absorbed by our bodies.

Aside from being water-soluble and being absorbed better by the body, there are many ways in which nano CBD is better than regular CBD. Another benefit of nano CBD products such as Ultradiol Ultragels is a faster CBD absorption rate. Testing on our nano-CBD products have shown that within just 30 minutes of ingestion, on average, 350ng/ml of CBD was present in the bloodstream.

Ultragels from Ultradiol also offer a longer shelf life than other CBD products and show no signs of degradation even at high temperatures for prolonged periods.

Undeniably though, the most significant benefit of nano-CBD like Ultragels, is the increased bioavailability rate. According to researchers, CBD, when having undergone nano emulsification, offers up to 20 times higher bioavailability rate than that of regular CBD. With that in mind, you can clearly see how a nano CBD product could be much more beneficial to consumers than regular CBD. Not only through better absorption and higher bioavailability but also through not having to take excessive doses of CBD and waste money on CBD that isn’t even reaching the bloodstream.


Not your regular CBD - Ultradiol products are manufactured according to the Whole Plant Principle and use a proprietary technology to enhance overall bioavailability. We believe that the closer the manufacturer comes to assembling the chemical profile of the whole plant, the safer & more effective the end product will be. 20x more bio-available than regular CBD.